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What is EDTA Calcium Disodium (Ethylenediaminetetraacetic Acid Calcium Disodium)?

EDTA in general is a substance which removes undesirable metals from the body. Many metals, including lead, mercury, and cadmium are poisonous to the body. Lead and cadmium levels are directly correlated with high blood pressure. EDTA is a chemical compound that binds minerals and metals like chromium, iron, mercury, copper, aluminum, nickel, zinc, calcium, cobalt, manganese, and magnesium to have them removed from the body so as for them to not have any adverse effects on the individual.

All metals, even essential nutrients, are toxic if taken in excess or when not situated appropriately. EDTA fixes this by normalizing the distribution of most metallic elements in the body. EDTA improves calcium and cholesterol metabolism by eliminating metallic elements in the body by eliminating metallic catalysts which cause damage to cell membranes by producing "oxygen free radicals". EDTA helps to prevent the production of harmful free radicals, and thus helps prevent atherosclerosis, cancer, diabetes, and other diseases of aging before they can even begin. Edetate calcium disodium has several synonyms including: calcium disodium edathamil, Calcium EDTA (CaEDTA), calcium disodium edetate, calcium edetate, CaNa2 EDTA, calcium disodium ethylenediaminetetra-acetate and sodium calcium edetate.

CaEDTA or Calcium Disodium EDTA is a pharmaceutical grade chelating agent designed to bind and render inactive certain trace metals and used as a chelating agent in the treatment of lead poisoning. Aside from chelating lead, CaEDTA also chelates and eliminates zinc from the body. In essence, Calcium Disodium EDTA works to increase the excretion of lead, which is absorbed in the bones. As the bones begin to demineralize with age, in what is more popularly known as osteoporosis, the lead is slowly released into the blood stream and the elderly are re-poisoned, compounding their health problems, like dementia and high blood pressure. CaEDTA also chelates cadmium, copper, iron and manganese, but to a much lesser extent than either lead or zinc. CaEDTA is relatively useless in treating mercury, gold or arsenic poisoning. Calcium disodium ethylenediaminetetraacetic acid (CaNa2EDTA) chelation therapy works by pulling out heavy metals from damaged hearts and heart valves, as well as from hidden stores within blood vessels, kidneys, and more. It has even been shown to pull out the calcifications from arteries. The results of this therapy have literally given patients a new lease on life and have saved the lives of many people across the globe for decades.

NOTE: Do not confuse CaEDTA with Edetate Disodium. The latter should not be used for lead poisoning, as this error may cause severe hypocalcemia. The two EDTA drugs have established names that are easily confused and both are referred to in clinical practice as "EDTA." This confusion has resulted in medication errors in which some patients have received the wrong drug, which has been fatal in some cases or caused serious adverse reactions in others. The error is especially dangerous when edetate disodium is erroneously given to a patient who is supposed to receive edetate calcium disodium.

What is EDTA Calcium Disodium used for and who uses it?

As a preservative and sequestrant/chelating agent, this white, odorless, crystalline powder, with a faint, salty taste has a variety of uses both in medicine as well as in food products. In canned and carbonated soft drinks, CaEDTA is used for flavor retention; for color retention in canned white potatoes, cooked canned clams, cooked and canned dried lima beans, and processed dried pinto beans; to retard struvite (crystal) formation in crab meat; as a preservative in dressings, mayonnaise, sandwich spreads, and margarine; and to prevent gushing in fermented malt beverages. Medically, CaEDTA is used as a chelating agent to detoxify poisoning by lead and other heavy metals.

This form of EDTA has the longest history of not only reversing all sorts of cardiovascular diseases including hypertension, angina, and arrhythmias, but also neutralizing plaques that were blocking important neck, heart and leg vessels in which surgery was not advisable. It removes cholesterol plaque and lowers cholesterol. In fact, CaEDTA is the same ingredient they put in blood tubes in the laboratory to keep blood from prematurely clotting.

How pure is your EDTA Calcium Disodium?

This EDTA (Ethylenediaminetetraacetic Acid Calcium Disodium) powder is assayed by the manufacturer to be 99.6% (normal range 99.0 to 101.0%). You will receive a white crystalline powder that contains no fillers, taste additives, or anti-caking agents. The remaining 0.4% by weight are inactive byproducts of the extraction.

What is the daily suggested dose of EDTA Calcium Disodium?

Please be advised that Calcium Disodium Edetate is capable of producing toxic and potentially fatal effects. The dosage schedule must be strictly followed and the recommended daily dose must not be exceeded at any time. For oral chelation purposes your optimal single dose should be approximately 1 gram CaEDTA per 100 pounds of body weight. For example, a 200 pound male or female would have an optimal single dose of approximately 2 grams taken three times per day for a total EDTA daily dose of 6 grams. One level teaspoon will supply approximately 3498 milligrams, or just about 3.5 grams for the bulk density of this CaEDTA powder.

As always, if you have concerns or questions, consult a physician or a health care professional before taking any supplements. Before taking any kind of medicine, check with your doctor to ensure that the supplement you want to take is right for you. You may be allergic or you may have a sensitive stomach which may raise the need for special instruction as far as dosage goes.

Possible Interactions with EDTA Calcium Disodium

Because CaEDTA is a very effective mineral chelation agent you will want to avoid taking mineral supplements with or at the same time as your CaEDTA doses. Mineral supplements can and should be taken with meals if you take your EDTA dose between meals (during your fasting periods), but you may want to take a full spectrum mineral supplement that includes the minerals Calcium, Magnesium, Zinc, Chromium and Selenium. You may also consider taking your CaEDTA chelation doses for one week and then go off for one week while alternating your mineral supplementation during your non-EDTA weeks.

NB CaEDTA is contraindicated in patients with anuria. It should be used with extreme caution and with dosage adjustment in patients with diminished renal function.

Precautions and Potential side effects of EDTA Calcium Disodium

This recommended dose of 1 gram per 100 pounds of body weight may or may not be suited to all individuals. CaEDTA in higher doses and occasionally at doses approximating this recommended dose may cause gastric upset and/or nausea is some individuals, and may act as a gastrointestinal irritant in some patients, producing diarrhea, abdominal cramps, and vomiting. Other side effects manifested in a relatively small percentage of patients were leg and other muscle cramps, weakness, malaise, and albumin or red cells in the urine. None of the adverse effects is considered to be serious when detected early. Excessive doses may lead to renal toxicity. Your personally optimal dose for CaEDTA may by more or less than the recommended dose depending upon your tolerance and accommodation to this product when taken during fasting periods.

This information is NOT a substitute for medical advice. ALWAYS consult your doctor or pharmacist. Do not use any dietary supplement as a replacement for conventional care, or as a reason to postpone seeing a doctor about a medical problem. Tell all your health care providers about any complementary and alternative practices you use. Give them a full picture of what you do to manage your health. This will help ensure coordinated and safe care.

Taste, Solubility, and Preparation needed for CaEDTA Supplementation

A heavy metal chelating agent, edetate calcium disodium (CaEDTA) occurs as an odorless, white, crystalline powder or granules and is a mixture of dihydrate and tri hydrate forms. It has a slight saline taste, freely soluble in water and very slightly soluble in alcohol. CaEDTA powder does not have an unpleasant taste (a little salty tasting perhaps) and can be taken orally with juice or water. Bear in mind, however, that EDTA will dissolve best in hot and slightly alkaline water (with pH above 7.2) and CaEDTA will not dissolve readily in acidic water or acidic juices such as citrus juices and drinks or lemonade. While a few EDTA sellers recommend taking this product sublingually for greater absorption, sublingual administration of this CaEDTA powder is not necessary and can be a challenging and an unpleasant experience owing to EDTA's positive heat of solution (it gives off heat as it dissolves). Taking CaEDTA orally by dissolving it in a glass of warm or hot water and drinking is by far the easiest and most practical way to take oral EDTA in this author's opinion.

Taking your CaEDTA doses while fasting is the most effective way to assure the highest absorption rates and the greatest chelation benefits from this product. Since CaEDTA is a very effective chelation agent it will bind with whatever minerals you have in your digestive tract if you take it with food or meals. For greatest effect you should take your CaEDTA doses three times per day while fasting. The first dose should be taken upon waking in the morning at least one half hour prior to breakfast. Your second dose should be taken in the afternoon at least 2 hours after lunch and at least one hour before dinner. Your third dose should be taken at least 2 to 3 hours after dinner or as close to your bedtime as practical.

References & Further Research

Reversible myocarditis due to chronic lead poisoning
Chronic lead poisoning in childhood, though uncommon, remains a problem in many parts of the world. Recovery after treatment with CaNa2 EDTA was apparently complete.

Cardiovascular actions of lead and relationship to hypertension: A Review
Chronic and acute lead poisoning cause overt, clinical symptoms of cardiac and vascular damage with potentially lethal consequences. Myocarditis, electrocardiographic disturbances, heightened catecholamine arrhythmogenicity, altered myocardial contractile responsiveness to inotropic stimulation, degenerative structural and biochemical changes affecting the musculature of the heart and vasculature, hypertension, hypercholesterolemia, atherosclerosis, and increased vascular reactivity to alpha-adrenergic agonists have been among the reported cardiovascular disturbances linked to lead poisoning.

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